Clarithromycin use in hypersomnia pdf

The investigators therefore propose a pilot, crossover trial comparing clarithromycin to placebo for the treatment of hypersomnia in patients with excess gabaa potentiation. Secondary endpoints will include a decrease in pvt lapses and changes in epworth, stanford, and fosq sleep scales. Learn about side effects, warnings, dosage, and more. In animal studies, clarithromycin caused birth defects. Clarithromycin responders were significantly younger than nonresponders.

Clarithromycin oral tablet biaxin is used to prevent and treat certain bacterial infections. Take this medication by mouth with food as directed by your doctor, usually once daily. Use effective birth control to prevent pregnancy while you are using this medicine. Improvement in daytime sleepiness with clarithromycin in. Further evaluation of this novel therapy is needed. This was a fiveweek, randomized, placebocontrolled, doubleblind, crossover trial of clarithromycin 500 mg with breakfast and lunch, in patients with hypersomnolence syndromes excluding narcolepsy with cataplexy and evidence for abnormal cerebrospinal fluid potentiation of gabaa receptors. Summary of research into clarithromycin as a hypersomnia treatment. The primary endpoint will be a decrease in pvt reaction time. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.

Clarithromycin is the generic form of the brandname prescription drug biaxin, an antibiotic used to treat bacterial infections. Summary of research into clarithromycin as a hypersomnia. Clinical experience article in journal of psychopharmacology 287 december 20 with 125 reads. Improvement in daytime sleepiness with clarithromycin in patients with gabarelated hypersomnia. The results are yet to be published but a clinical trial has been completed by emory university and anecdotally there were very promising results. Studies have shown that clarithromycin can reduce sleepiness, but researchers do not know how clarithromycin does this. Lynn marie trotti, md the term hypersomnia describes a group of symptoms that includes severe daytime sleepiness and sleeping long periods of time more than 10 hours per night. Sleep clinical trials clarithromycin for the treatment of hypersomnia. Clarithromycin dosing, indications, interactions, adverse. The purpose of this study is to evaluate a medication called clarithromycin for treating sleepiness in two related conditions, narcolepsy without cataplexy and idiopathic hypersomnia. Gaba is known to promote sleep and decreased consciousness, and many patients with cns hypersomnia have been found to have endogenous gabaa receptor hyperreactivity.

Clarithromycin may be useful in the treatment of hypersomnia associated with enhancement of gabaa receptor function. Antibiotic may decrease eds in gabarelated hypersomnia. Clarithromycin is often used for pneumonia, bronchitis, and. Clarithromycin for the treatment of hypersomnia full. Clarithromycin mechanisms in hypersomnia syndromes full. However, it is not known whether these effects would occur in humans. Asking your doctor about clarithromycin have you been reading some of the articles on the web about the benefits of clarithromycin for people with idiopathic hypersomnia. Flumazenil, a known gabaa antagonist, has been shown to reduce symptoms in these patients, but its use may be impractical. Find patient medical information for clarithromycin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Subjects could not have moderate or severe sleep apnea, severe periodic limb movement disorder with arousals, metabolic disorders thought to explain their hypersomnia symptoms, hypocretin deficiency, or cataplexy.